Started by Handshake, April 16, 2017, 11:59:06 AM
QuoteBackground/Aim: 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is the main psychoactive ingredient of bufo alvarius toad venom and is present in a variety of plants/shrubs. Anecdotal reports are that synthetic and organic preparations of 5-MeO are used for spiritual and recreational motives and may have psychotherapeutic benefit. However, there is no published evidence about the epidemiology of 5-MeO consumption, limiting understanding of the scope of use and possible harms/benefits of consumption. Therefore, we examined patterns of use, motivations for consumption, and acute subjective effects of 5-MeO-DMT among English-speaking 5-MeO-DMT users. Method: Using internet-based advertisements, we recruited 515 respondents (Mage=35.4, SD=11.7; Male=79%; White/Caucasian=86%; United States=42%) to complete a web-based survey. Results: Most people consumed 5-MeO-DMT infrequently (once a year or less), with the motivation of spiritual exploration, and consumed 5-MeO-DMT less than 4 times in their lifetime. Less than half of the sample (39%) reported repeated consumption in the same session, and very low rates of craving (8%), or legal (1%), medical (1%), or psychiatric (1%) problems due to 5-MeO-DMT use were reported. Most respondents (>80%) reported a variety of acute experiences (e.g., awe or awesomeness, amazement, loss of time and space, and difficulty putting experience into words) and relatively fewer (40%-66%) experienced acute challenging experiences (e.g., fear, anxiousness, felt like they were dead or dying). Furthermore, of those who reporting being diagnosed with psychiatric disorders, most reported that 5-MeO-DMT contributed to a decrease in symptoms related to post-traumatic stress disorder (79%), depression (77%), anxiety (69%), and substance use (~63%). Conclusion: Findings suggest that 5-MeO-DMT is used infrequently, primarily for spiritual exploration, has low addiction liability, and might have psychotherapeutic effects. However, there are no published studies examining the safety of 5-MeO administration in humans. Therefore, we recommend that future research examine the safety and pharmacokinetics of 5-MeO-DMT administration in humans using rigorous experimental designs.
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