Main Menu

New study on 5-MeO use in naturalistic setting & improvements in depression

Started by Bancopuma, March 11, 2019, 01:37:49 PM

Previous topic - Next topic


Interesting new study on 5-MeO, fresh off the press:

Davis, A.K., So, S., Lancelotta, R., Barsuglia, J. & Griffiths, R.R. (2018) 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. The American Journal of Drug and Alcohol Abuse, 10.1080/00952990.2018.1545024

Background: A recent epidemiological study suggested that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used for spiritual and recreational reasons is associated with subjective improvement in depression and anxiety. Further exploration of the potential psychotherapeutic effects of 5-MeO-DMT could inform future clinical trials. Objectives: We examined self-reported improvement in depression and anxiety among people who use 5-MeO-DMT in a group setting with structured procedures guiding dose and administration of 5-MeO-DMT. Such procedures also include activities for the preparation of, and support during/following sessions, which are similar to procedures used in clinical trials of hallucinogen administration. Next, we examined whether depression or anxiety were improved following use, and whether the acute subjective effects (mystical/challenging) or beliefs about the 5-MeO-DMT experience were associated with improvements in these conditions. Methods: Respondents (n = 362; Mage = 47.7; Male = 55%; White/Caucasian = 84%) completed an anonymous web-based survey. Results: Of those reporting having been diagnosed with depression (41%) or anxiety (48%), most reported these conditions were improved (depression = 80%; anxiety = 79%) following 5-MeO-DMT use, and fewer reported they were unchanged (depression = 17%; anxiety = 19%) or worsened (depression = 3%; anxiety = 2%). Improvement in depression/anxiety conditions were associated with greater intensity of mystical experiences and higher ratings of the spiritual significance and personal meaning of the 5-MeO-DMT experience. There were no associations between depression or anxiety improvement and the intensity of acute challenging physical/psychological effects during the 5-MeO-DMT experience. Conclusions: Future prospective controlled clinical pharmacology studies should examine the safety and efficacy of 5-MeO-DMT administration for relieving depression and anxiety.


Thanks for sharing, Bancopuma!

I made some edits to make it look prettier, but when pasting information from external sources it is best to make sure you paste Unformatted Text instead of copy-pasting directly. If you paste formatted text, the editor on the site will try and add formatting tags which don't always work properly.

At any rate, I'll get out of the way. May the discussion regarding this paper flow freely!


Thank you dude, good to know for future ref! And yes excellent to see an increase in interesting studies on 5-MeO appearing in the last year or so..  :)