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Messages - Flux

#106
QuoteIs said interphase within the Light of Lights common with this molecule?  And do most people here believe that the nickname, "The God Molecule" is appropriate?  A lot of folks at the Nexus are hardcore atheists and challenge any notion of NN-DMT being a portal to the Spirit/God-self. Is 5-MeO more apt to lead to deeper, more religious states of perception?  Or is it like any other psychedelic, which is always relative to the traveler? 

All very pertinent questions and most welcome in stimulating the dialogue here. For me, the 'light' is quite paradoxical, in that it is simultaneously dark though nonetheless all pervasive, while occasionally it may emanate from a tunnel (as in traditional depictions of white light experiences - or that of the n-n-dmt topography) for me 5-MeO seems to be more of an all encompassing and subsuming, enveloping light.

As one inculcated by religious education as a child and long since freed of this cognitive shackle, I too find the term 'god' problematic in its connotation, but this is in part a semantic issue. Beyond the orthodox claims of exclusivity to 'God', as a linguistic construct it seems clear that across human cultures we are referring to the same thing. However, rather than 'a creator or ruler of the universe and source of all moral authority' , the god encountered in 5-MeO space seems to be more aligned with Eastern traditional concepts of 'Godhead', Brahman or Paramatman as glimpsed through the Atman, thus the 5-MeO space resonates with such states as samadhi, nirvana, moksha, etc.

If 5-MeO is more apt to lead to deeper, more religious states of perception, this may well be be as you suggest, relative and subjective. However, given the experience invoked by this molecule - of complete unification of mind, body, spirit, consciousness, time, space, sound and all other perceptual modes of existence, a spiritual/religious interpretation is likely. Further, unlike other entheogens which have a 'build up' to such peak states, 5-MeO's abrupt plunging into complete transcendence of 'self' and utter dissolution of subject/object positions, could make such a numinous experience more conducive to a religious/spiritual ontology and thus a more helpful framework with which to conceptualise and articulate such utter ineffability . 
#107
Introductions/Newbies / Re: Flux - Intro
May 09, 2017, 08:30:53 PM
I thought  so too - cant remember where I found it but you could maybe screen shot or save a still jpeg and reverse google image search it
#108
Yes - there are more.. try now that you have made an introduction :)
#109
Introductions/Newbies / Re: Flux - Intro
May 09, 2017, 12:28:28 AM
Hola hermano :) (I just cliqued to the id after replying to your intro post)
#110
Introductions/Newbies / Re: Introduction to Truth
May 09, 2017, 12:26:47 AM
Hi Truth and welcome,

Would love to hear a full report - particularly if this is a plant-based source of 5-MeO such as ayahuasca as there is some academic/scientific contention as to the pharmacology of plants such as Chalipopnga actually containing 5-MeO-Dmt or not. Qualitative reports are most valuable in forwarding the evidence that there is indeed trace amounts that become significantly activated by the presence of an MAOI,

Arohanui :)
#111
Hi Rising spirit and welcome,

The 5-MeO experience is indeed the ultimate transcendence of our normal waking state and the individuated mode-of-being.

I do believe that such a level of unitary consciousness can be reached, or at the very least glimpsed with the other medicines such as the ones you mention, usually at the peak state of very large doses. I hope these previous experiences serve you well and that you glean some useful knowledge in preparation for meeting the God Molecule.

blessings :),

Flux
#112
Hi Alan and welcome,

Thank you for sharing this (I think the study link was one of the very first posts here).

The timing of this study and the forum here feels like a notable synchronisation with the momentum 5-MeO is gathering and I imagine this will help will increase your number of respondents to build a solid-sized sample group.

Please feel free to share any pertinent papers or journal articles that you may be aware of in the science section so that we can build a database of 5-MeO research.

cheers, Flux :) 
#113
Agurell S, Holmstedt B & Lindgren JE, 1969, 'Metabolism of 5-methoxy-N,N dimethyltryptamine-14C in the rat', Biochemical Pharmacology, vol. 18, no. 12, pp. 2771-2781, doi.org/10.1016/0006-2952(69)90185-3, http://www.sciencedirect.com/science/article/pii/0006295269901853

Abstract

The metabolism of 5-methoxy-N,N-dimethyltryptamine-14C has been investigated in the rat after i.p. injection (5 mg/kg). About 59–65 per cent of the radioactivity is excreted in the 24 hr urine, 4–9 per cent is eliminated in the faeces and 1 per cent as carbon dioxide during this time. Of the metabolites appearing in the urine 54 per cent is present as 5-methoxyindoleacetic acid, 9 per cent as bufotenine, 23 per cent as bufotenine glucuronide and 14 per cent as 5-hydroxyindoleacetic acid. Considerable differences in the metabolism occurred at high dose levels. 5-Methoxyindoleacetic acid-3H is not demethylated to 5-hydroxyindoleacetic acid.I.p. administered 6-hydroxy-5-methoxy-N,N-dimethyltryptamine-3H is excreted mainly unchanged and to a minor degree as conjugate and as 6-hydroxy-5-methoxyindoleacetic acid.
5-Methoxy-N,N-dimethyltryptamine is not 6-hydroxylated to a detectable degree in vivo and 6-hydroxylation is apparently of no importance for the psychotropic activity of 5-methoxy-N,N-dimethyltryptamine.
#114

Squires RF, 1975, 'Evidence That 5-Methoxy-N, N-Dimethyl Tryptamine Is a Specific Substrate For Mao-A in The Rat: Implications For The Indoleamine Dependent Behavioural Syndrome', Journal of Neurochemistry, vol. 24, no. 1, pp. 47-50, DOI: 10.1111/j.1471-4159.1975.tb07626.x, http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1975.tb07626.x/full

Abstract

A simple method for the separation of 5-hydroxyindoleacetic acid (5-HIAA) and 5-methoxyindoleacetic acid (5-MeOIAA) on columns of non-ionic polystyrene (Amberlite XAD-2) is described. Administration of 5-methoxy-N, N-dimethyl-tryptamine (5-MeODMT) 2 mg/kg i. p. to rats results in a sixfold increase in brain 5-MeOIAA within 15 min. This increase is blocked by the selective inhibitor of MAO-A, clorgyline, but not by the selective inhibitor of MAO-B, deprenyl, indicating that 5-MeODMT is deaminated almost entirely by MAO-A. The apparent 5-MeOIAA concentration in the brains of L-tryptophan loaded rats is not reduced by clorgyline and deprenyl, either singly or in combination, indicating that most of this fluorescence is due to other, unidentified substances. The apparent concentration of 5-HIAA in rat brain, minus 5-MeOIAA, is unaffected by deprenyl and reduced by clorgyline. However, clorgyline and deprenyl in combination reduced 5-HIAA values below those obtained with clorgyline alone. It is concluded that very little 5-MeODMT or other 5-methoxyindoleamines are formed endogenously in rat brain, and that the stereotyped syndrome of hyperactivity and tremors produced in rats by pretreatment with MAO inhibitors and L-tryptophan is dependent on the formation of an N-substituted derivative of 5-HT which is at least partly deaminated by MAO-B to 5-HIAA
#115
Alhaider AA, Hamon, M & Wilcox, GL, 1993, 'Intrathecal 5-methoxy-N, N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors', European Journal of Pharmacology, vol. 249, no. 2, 9, pp. 151-160, https://www.sciencedirect.com/science/article/pii/001429999390427J

Abstract

The antinociceptive effects of intrathecally administered 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), a potent 5-HT receptor agonist, were studied in three behavioral tests in mice: the tail-flick test and the intrathecal substance P and N-methyl-D-aspartic acid (NMDA) assays. Intrathecal administration of 5-MeO-DMT (4.6–92 nmol/mouse) produced a significant prolongation of the tail-flick latency. This action was blocked by 5-HT3 and γ-aminobutyric acidA (GABAA) receptor antagonists but not by 5-HT2, 5-HT1A, 5-HT1B or 5-HT1S receptor antagonists. Binding studies indicated that 5-MeO-DMT had very low affinity for 5-HT3 receptors. 5-MeO-DMT inhibited biting behavior while increasing scratching behavior induced by intrathecally administered substance P. The inhibition of biting behavior was antagonized by intrathecal co-administration of 5-HT1B and GABAA receptor ntagonists while 5-HT1A, 5-HT1S, 5-HT2 and 5-HT3 receptor antagonists had no effect. 5-MeO-DMT-enhanced scratching behavior was inhibited by all the antagonists used except ketanserin and bicuculline, suggesting the involvement of 5-HT1A, 5-HT1B, 5-HT1S, 5-HT3 and GABAA receptors. NMDA-induced biting behavior was inhibited by 5-MeO-DMT pretreatment; this action was antagonized by 5-HT1B, 5-HT3 and GABAA receptor antagonists. The involvement of these receptors in 5-MeO-DMT action suggests that it may promote release of 5-HT (5-hydroxytryptamine, serotonin).
#116
Wallach JV, 2009, 'Endogenous hallucinogens as ligands of the trace amine receptors: A possible role in sensory perception', Medical Hypotheses, vol. 72, no. 1, pp. 91-94, http://www.sciencedirect.com/science/article/pii/S0306987708003988

Abstract

While the endogenous hallucinogens, N,N-dimethyltryptamine, 5-hydroxy-N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyltryptamine, have been acknowledged as naturally occurring components of the mammalian body for decades, their biological function remains as elusive now as it was at the time of their discovery. The recent discovery of the trace amine associated receptors and the activity of DMT and other hallucinogenic compounds at these receptor sites leads to the hypothesis that the endogenous hallucinogens act as neurotransmitters of a subclass of these trace amine receptors. Additionally, while activity at the serotonin 5-HT2A receptor has been proposed as being responsible for the hallucinogenic affects of administered hallucinogens, in their natural setting the 5-HT2A receptor may not interact with the endogenous hallucinogens at all. Additionally 5-HT2A agonist activity is unable to account for the visual altering effects of many of the administered hallucinogens; these effects may be mediated by one of the endogenous hallucinogen trace amine receptors rather than the serotonin 5-HT2A receptor. Therefore, activity at the trace amine receptors, in addition to serotonin receptors, may play a large role in the sensory altering effects of administered hallucinogens and the trace amine receptors along with their endogenous hallucinogen ligands may serve an endogenous role in mediating sensory perception in the mammalian central nervous system. Thus the theory proposed states that these compounds act as true endogenous hallucinogenic transmitters acting in regions of the central nervous system involved in sensory perception
#117
Archer T, Minor BG, Post C, 1985, 'Blockade and reversal of 5-Methoxy-N, N-Dimethyltryptamine-induced analgesia following noradrenaline depletion', Brain Research, vol. 333, no. 1, pp. 55-61, http://www.sciencedirect.com/science/article/pii/0006899385901234

Abstract

The acute effects of the 5-hydroxytryptamine agonist, 5-Methoxy-N, N-dimethyltryptamine (5-MeO-DMT), upon pain sensitivity, using shock titration, tail-flick and hot-plate methods, in noradrenaline- and 5-hydroxytryptamine-depleted rats were examined. Noradrenaline depletion, following the systemic administration of N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4, 2 × 50 mg/kg, i.p.), caused a reversal of the analgesic effect of 5-MeO-DMT on shock-titration from hypo- to hypersensitivity, and a total blockade of the antinociceptive effect of 5-MeO-DMT upon pain responses in the hot-plate and tail-flick tests. Pretreatment with eitherp-chloroamphetamine (2 × 10 mg/kg) orp-chlorophenylalanine (200, 100, 100 mg/kg), that depletes central 5-hydroxytryptamine stores, failed to alter the analgesia caused by acute 5-MeO-DMT. Strong evidence is provided for the effect of central noradrenaline depletion upon the analgesic effect of the 5-HT agonist. These findings suggest an important tonic influence of the noradrenaline system upon the descending spinal 5-HT pathway in rats.
#118
Van Den Buuse M, Ruimschotel E, Martin S, Risbrough VB, Halberstadt AL, 2011, 'Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT1A receptor knockout mice: Implications for schizophrenia', Neuropharmacology, vol. 61, nos. 1–2, pp. 209-216,
http://www.sciencedirect.com/science/article/pii/S0028390811001468

Abstract

Serotonin-1A (5-HT1A) receptors may play a role in schizophrenia and the effects of certain antipsychotic drugs. However, the mechanism of interaction of 5-HT1A receptors with brain systems involved in schizophrenia, remains unclear. Here we show that 5-HT1A receptor knockout mice display enhanced locomotor hyperactivity to acute treatment with amphetamine, a widely used animal model of hyperdopaminergic mechanisms in psychosis. In contrast, the effect of MK-801 on locomotor activity, modeling NMDA receptor hypoactivity, was unchanged in the knockouts. The effect of the hallucinogen 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) was markedly reduced in 5-HT1A receptor knockout mice. There were no changes in apomorphine-induced disruption of PPI, a model of sensory gating deficits seen in schizophrenia. Similarly, there were no major changes in density of dopamine transporters (DAT) or dopamine D1 or D2 receptors which could explain the behavioural changes observed in 5-HT1A receptor knockout mice. These results extend our insight into the possible role of these receptors in aspects of schizophrenia. As also suggested by previous studies using agonist and antagonist drugs, 5-HT1A receptors may play an important role in hallucinations and to modulate dopaminergic activity in the brain.
#119
Gillin JC, Tinklenberg J, Stoff DM & Wyatt RJ, 1976, '5 Methoxy N,N dimethyltryptamine: behavioral and toxicological effects in animals', Biological Psychiatry, vol. 11, no. 3, pp. 355-8, https://www.researchgate.net/publication/22334810_5_Methoxy_NN_dimethyltryptamine_behavioral_and_toxicological_effects_in_animals

Abstract

These studies indicate that 5 MeO DMT has potent, rapidly appearing effects in the central nervous system. It has fatal effects in sheep at low doses, but not in monkeys, rats, or mice.
#120
Stoff DM, Gorelick DA, Bozewicz T, Bridger WH, Gillin JC & Wyatt RJ, 1978, 'The indole hallucinogens, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), have different effects from mescaline on rat shuttlebox avoidance', Neuropharmacology, vol. 17, no. 12, pp. 1035-40,  https://www.sciencedirect.com/science/article/pii/0028390878900308

Abstract

The indole hallucinogenic drugs, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), had a different psychopharmacological profile from mescaline on rat shuttlebox avoidance; the differences were strain and/or baseline-dependent. N,N-dimethyltryptamine and 5-MeO-DMT shared dose response disruptive effects with mescaline on avoidance behaviour in two rat strains who were performing the conditioned avoidance response at a high baseline (i.e. during acqusition in Fischer 344s—Experiment 1; on pretrained good performing hooded rats—Experiment 2). N,N-dimethyltryptamine and 5-MeO-DMT were without an effect when the baseline conditioned avoidance response was low (i.e. during acquisition in Zivic-Millers, Hoods or Roman Low Avoiders—Experiment 1; on pretrained poorly performing hooded rats—Experiment 2) but mescaline was facilitatory in these situations. There were strain-related differences in sensitivity to the drugs with Roman High Avoiders insensitive to DMT, 5-MeO-DMT and mescaline, while Fischer 344s were the most sensitive to these three drugs. The relative potency of these three hallucinogens in disrupting avoidance behavior (5-MeO-DMT > DMT > mescaline), in terms of mg/kg paralleled reports of their relative potency on central serotonergic activity. The facilitatory effect produced by mescaline, but not produced by DMT nor 5-MeO-DMT, may be related to the findings that mescaline has a stronger action on the catecholaminergic system than the indoles