Started by celestino, June 08, 2019, 12:25:19 PM
Quote from: celestino on June 12, 2019, 01:19:03 PMthe danger is if 5 is taken orally with maoi , NOT RECTALLY.
Quote from: RoundAbout on June 13, 2019, 10:43:51 AMWhy would oral + MAOI be more dangerous than rectal + MAOI?
Quote from: celestino on June 14, 2019, 01:27:12 AMhi,it is a bit like cooking in 2 different pots, the substances don´t mix up, they work from different places, so no danger.
Quote from: physics envy on June 14, 2019, 05:43:59 PMQuote from: RoundAbout on June 13, 2019, 10:43:51 AMWhy would oral + MAOI be more dangerous than rectal + MAOI? Generally oral ingestion of a substance goes through the liver and is broken down/converted, while rectal administration may or may not go through the liver.I don't know all the details, but from reading up on using cannabis oil suppositories, it depends on how deep you administer.If you stay in the first 1.5inches or so of the rectum, the substance does not get routed through the liver, but if you insert deeper, the substance may indeed be routed through the liver.I don't know if this affects 5+maoi combinations at all, but I think that's the main difference between oral and rectal administration.
Quote from: celestino on June 12, 2019, 01:19:03 PMhi humble Voyager,would you please tell me the facts and the names of the people who have died because of 5 + maoi?in yopo it is used maoi and no problem, the danger is if 5 is taken orally with maoi , NOT RECTALLY.Will you please tell me where from did you get this information? thanksall the best. celestino
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