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Topics - Flux

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31
Hong-Wu S,  Xi-Ling J, Winter JC & Yu AM, 2010, 'Psychedelic 5-Methoxy-N,N-Dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions', Current Drug Metabolism, vol. 11, no. 8, pp. 659-666, doi 10.2174/138920010794233495, https://www.ncbi.nlm.nih.gov/pubmed/20942780

Abstract

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiological and behavioral changes. 5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metabolite, bufotenine, while it is mainly inactivated through the deamination pathway mediated by monoamine oxidase A (MAO-A). 5-MeO-DMT is often used with MAO-A inhibitors such as harmaline. Concurrent use of harmaline reduces 5-MeO-DMT deamination metabolism and leads to a prolonged and increased exposure to the parent drug 5-MeO-DMT, as well as the active metabolite bufotenine. Harmaline, 5-MeO-DMT and bufotenine act agonistically on serotonergic systems and may result in hyperserotonergic effects or serotonin toxicity. Interestingly, CYP2D6 also has important contribution to harmaline metabolism, and CYP2D6 genetic polymorphism may cause considerable variability in the metabolism, pharmacokinetics and dynamics of harmaline and its interaction with 5-MeO-DMT. Therefore, this review summarizes recent findings on biotransformation, pharmacokinetics, and pharmacological actions of 5-MeO-DMT. In addition, the pharmacokinetic and pharmacodynamic drug-drug interactions between harmaline and 5-MeO-DMT, potential involvement of CYP2D6 pharmacogenetics, and risks of 5-MeO-DMT intoxication are discussed.

32
Media/Resources / 5-MeO-DMT User's Guide
« on: May 01, 2017, 03:01:30 AM »
The following is a document published by Martin Ball as "a clear and easy to understand guide in question and answer format concerning the use of 5-MeO-DMT as an entheogenic tool for expansion of human awareness" 5-MeO-DMT Users Guide

33

Wade D & Weil A, 1994, ‘Bufo alvarius: A Potent Hallucinogen of Animal Origin’, Journal of Ethnopharmacology, vol. 41, nos. 1-2, pp. 1-8, https://www.ncbi.nlm.nih.gov/pubmed/8170151

Abstract:

Anthropologists have long speculated that ancient peoples of Mesoamerica used a toad, Bufo marinus, as a ritual intoxicant. This hypothesis rests on many iconographic and mythological representations of toads and on a number of speculative ethnographic reports. The authors reject B. marinus as a candidate for such use because of the toxicity of its venom. A more likely candidate is the Sonoran desert toad, Bufo alvarius, which secretes large amounts of the potent known hallucinogen, 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). The authors demonstrate that the venom of B. alvarius, although known to be toxic when consumed orally, may be safely smoked and is powerfully psychoactive by that route of administration. These experiments are the first documentation of an hallucinogenic agent from the animal kingdom, and they provide clear evidence of a psychoactive toad that could have been employed by Precolumbian peoples of the New World

34
Journal Articles / Identity of a New World Psychoactive Toad
« on: May 01, 2017, 02:55:02 AM »
Davis W & Weil A, 1992, ‘Identity of a New World Psychoactive Toad’, Ancient Mesoamerica, vol. 3, no. 1, pp. 51-59. DOI: 10.1017/S0956536100002297, https://www.researchgate.net/publication/232002148_Identity_of_a_New_World_Psychoactive_Toad

Abstract

Anthropologists have long speculated that ancient peoples of Mesoamerica used a toad, Bufo marinus, as a ritual intoxicant. This hypothesis rests on many iconographic and mythological representations of toads and on a number of speculative ethnographic reports. We reject B. marinus as a candidate for such use because of the toxicity of its venom. A more likely candidate is the Sonoran desert toad, Bufo alvarius, which secretes large amounts of the potent, known hallucinogen, 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT). We demonstrate that the venom of B. alvarius, though known to be toxic when consumed orally, may be safely smoked and is powerfully psychoactive by that route of administration. These experiments are the first documentation of a hallucinogenic agent from the animal kingdom, and they provide clear evidence of a psychoactive toad that could have been employed by Precolumbiae peoples of the New World.

35
Lyttle T, Goldstein, D & Gartz J,'Bufo Toads and Bufotenine: Fact and Fiction Surrounding an Alleged Psychedelic', Journal of Psychoactive Drugs, vol. 28 (3), pp. 267-290. https://www.ncbi.nlm.nih.gov/pubmed/8895112

Abstract:

This paper investigates the supposedly psychedelic Bufo toad and the allegedly psychedelic drug bufotenine, which is contained in the skin and glands of this toad. The bufo toad has held a place in human mythologies and medicines worldwide since archaic times. Used by ancient peoples for a variety of purposes, its most spectacular effects, according to lore, involve magical and shamanic or occult uses for casting spells and for divination. In the Middle Ages, the Bufo toad was celebrated as a panacea and persecuted as a powerful poison. More recently, in the 1960s the Bufo toad was resurrected as a countercultural icon, with people purportedly licking or smoking the secretions to get high. Bufotenine has been at the center of a scientific debate since its discovery in 1893. This paper examines the extensive literature surrounding the Bufo toad and bufotenine, and untangles many of the myths and the misinformation that continue to vex both science and popular reporting. Finally, to promote further investigation, a comprehensive bibliography is provided that charts the history of the Bufo toad and bufotenine.



36
Poetry and Art / Onyx Flux
« on: May 01, 2017, 02:41:55 AM »
Onyx Flux

Silver fractal shards pour into my sight,
spiralled out and piping in - a sudden liquid light.
Yielding to an emptiness, a space at once replete,
with boundless black expanse, infinite and complete.

Unfolding diamond-laden vista, quartz and crystalline, 
each-in-all and all-in-each, endless myriad facets shine.
In charged electric ether-sphere, a brilliant lightening white,
brings from depths within, an arcane obsidian night.

Sound vibrates this space in time and into being creates,
a vastly liminal zone; a pure awareness state.
An omnipresent force propels, the surge to rise and grow,
with pulsing, phasing current in eternal ebb and flow.

A vibratory purge, a harmonising clean,
Orgasmic oscillation of frequency unseen. 
In somatic symmetry of tension-borne release,
this fluid state of flux, reflects an inner peace.

Translucent beads of potency in molten motion course,
through quicksilver rivulets to the heart of source.
As Spirit moves in everything, everywhere and everywhen,
Its purity of perfection arrives at home again.

This body, I, a vessel see - the breath of life is me,
In gratitude of energy and re-membering to be.
From alpha to omega flows, eternal animation's shape,
Always here, always now- essence of is-ness agape.

As onyx mindscape dissolution, finds the centre core,
of true, eternal, love divine in soulgasm evermore.
Open - open - ever open... to receive with bliss; serenity,
in stillness grace abounds, wholly-holy integrity.

 

37
5-MeO-DMT Experiences and Testimonials / Onyx Flux
« on: May 01, 2017, 02:31:05 AM »
As a composite of impressions taken from (at the time of writing) a dozen or so experiences with vapourised synthetic 5-MeO-DMT, my testimonial takes the form of a poem in what I am drawn to as a more fluid way of articulating such ineffability.

Onyx Flux

Silver fractal shards pour into my sight,
spiralled out and piping in - a sudden liquid light.
Yielding to an emptiness, a space at once replete,
with boundless black expanse, infinite and complete.

Unfolding diamond-laden vista, quartz and crystalline, 
each-in-all and all-in-each, endless myriad facets shine.
In charged electric ether-sphere, a brilliant lightening white,
brings from depths within, an arcane obsidian night.

Sound vibrates this space in time and into being creates,
a vastly liminal zone; a pure awareness state.
An omnipresent force propels, the surge to rise and grow,
with pulsing, phasing current in eternal ebb and flow.

A vibratory purge, a harmonising clean,
Orgasmic oscillation of frequency unseen. 
In somatic symmetry of tension-borne release,
this fluid state of flux, reflects an inner peace.

Translucent beads of potency in molten motion course,
through quicksilver rivulets to the heart of source.
As Spirit moves in everything, everywhere and everywhen,
Its purity of perfection arrives at home again.

This body, I, a vessel see - the breath of life is me,
In gratitude of energy and re-membering to be.
From alpha to omega flows, eternal animation's shape,
Always here, always now- essence of is-ness agape.

As onyx mindscape dissolution, finds the centre core,
of true, eternal, love divine in soulgasm evermore.
Open - open - ever open... to receive with bliss; serenity,
in stillness grace abounds, wholly-holy integrity.

 




 

40
Media/Resources / Articles
« on: April 28, 2017, 05:20:05 AM »
ARTICLES

A New Craze Hops into the Drug Culture Fads: The quest for new highs has led some seekers to a new low--toad smoking. It's weird, it's illegal, and experts warn that it's probably dangerous, too, by Leo W. Banks, Los Angeles Times, 1994, https://erowid.org/archive/sonoran_desert_toad/LATimes.htm

A Toad on the Moon: Or a Brief Speculation on Chinese Psychoactive Toad Venoms, by Frederick R. Dannaway, n.d., https://sites.google.com/site/delawareteasociety/a-toad-on-the-moon-or-a-brief-speculation-on-chinese-psychoactive-toad-venoms

At the Crossroads of Ibogaine and 5-MeO-DMT: An Interview with Dr. Martin Polanco, by Wesley Thoricatha, Psychedelic Times, 2015, http://psychedelictimes.com/iboga/at-the-crossroads-of-ibogaine-and-5-meo-dmt-interview-with-dr-martin-polanco/

Bufo Alvarius; A Personal Story, by Anon, n.d., https://erowid.org/archive/sonoran_desert_toad/mystory.htm

Bufo alvarius: The Psychedelic Toad of the Sonoran Desert, by Albert Most, 1983, https://erowid.org/archive/sonoran_desert_toad/almost.htm

Bufo Alvarius: The Psychedelic Toad That Contains 5-Meo-Dmt, by Jennifer Sodini, 2016, http://www.evolveandascend.com/2016/04/30/bufo-alvarius-psychedelic-toad-contains-5-meo-dmt/

The Essential Guide to 5-MeO-DMT,

Farmer Bob's Good Life, by Ward Parkway, n.d., [url=https://erowid.org/archive/sonoran_desert_toad/farmer.htm]https://erowid.org/archive/sonoran_desert_toad/farmer.htm


Give the Ego a Break, Cate Montana, 2016, https://www.catemontana.com/2016/08/give-the-ego-a-break/#more-1124

Goodbye Ecstasy, Hello 5-Meo-DMT: New Designer Drugs are Just a Click Away, by David McCandless, The Guardian, 2004, https://www.theguardian.com/society/2004/feb/16/drugsandalcohol.drugs

In Search of Hallucinogenic Toad, by Vice Staff, Vice, 2015, https://www.vice.com/en_au/article/the-toad-prophet-464

Instant Samadhi: the 5-MeO-DMT toad sacrament, by Guy Crittenden, 2017 http://guycrittenden.blogspot.com.au/2017/06/instant-samadhi-5-meo-dmt-toad-sacrament.html

Just Say No, by Brendan Joel Kelly, Phoenix New Times, 2004, http://www.phoenixnewtimes.com/music/just-say-no-6438439

Misuse and Legend in the "toad licking" Phenomenon, Thomas Lyttle,1993, https://erowid.org/archive/sonoran_desert_toad/LaLaw.htm#Lyttle

More details about my new book: The Toad and the Jaguar, by Ralph Metzner, 2014, https://ralphmetznerblog.com/tag/5-meo-dmt/

Personal Story: My 5-MeO-DMT Experience, by Jenn Bowers, Reset Me, 2015 http://reset.me/personal-story/personal-story-my-5-meo-dmt-experience/

Practicing Death, by Tom Pinkson, Spirituality & Health, 2010, http://spiritualityhealth.com/articles/practicing-death

Psychedelic Research with Ibogaine and 5-MeO-DMT: An Interview with Dr. Joseph Barsuglia, by Wesley Thoricatha, Psychedelic Times, 2016, http://psychedelictimes.com/iboga/psychedelic-research-with-ibogaine-and-5-meo-dmt-an-interview-with-dr-joseph-barsuglia/

Psychoactive Toads- Will licking toads make you high?, Trancentral, n.d., https://trancentral.tv/psychoactive-toads/

Reports of 5-MeO-DMT Experiences, by Anonymous, Serendipity, 2015, http://www.serendipity.li/dmt/1st5meo.html

Risks associated with combining Bufo Alvarius with ayahuasca, ICEERS, 2017 http://news.iceers.org/2017/05/alert-bufo-alvarius-and-ayahuasca/?utm_content=buffer8e88b&utm_medium=social&utm_source=facebook.com&utm_campaign=buffer

Schedules of Controlled Substances: Placement of 5-Methoxy-N,N-Dimethyltryptamine into Schedule I of the Controlled Substances Act, A Rule by the Drug Enforcement Administration on 2010, Federal Register The Daily Journal of the United States Government, https://www.federalregister.gov/documents/2010/12/20/2010-31854/schedules-of-controlled-substances-placement-of-5-methoxy-nn-dimethyltryptamine-into-schedule-i-of

Simona€s Bufo Alvarius (Colorado River Toad) Guide, Simonthesorcerer, n.d., https://simonsblogpark.com/legalhigh/simons-bufo-alvarius-colorado-river-toad-guide/

Smoking Toad, by Larry Gallagher, Esquire Magazine, 1994, http://www.larrygallagher.com/articles/toad.pdf

Smoking Toad Venom€, All About Heaven, n.d., http://www.allaboutheaven.org/overload/451/107/smoking-toad-venom

The God Molecule, by Gerardo Ruben Sandoval Isaac, Reality Sandwich, 2017, http://realitysandwich.com/320490/the-god-molecule/

The Georgetown Drug Lab Bust: More Promising Young Lives Ruined for No Good Reason, By Armin Rosen, The Hit & Run blog, 2010 https://reason.com/blog/2010/10/26/the-georgetown-drug-lab-bust-m

The Nuclear Option: A Personal Story of Treating Social Anxiety with 5-MeO-DMT Psychedelic Therapy, by Wesley Thoricatha, Psychedelic Times, 2016, http://psychedelictimes.com/5-meo-dmt/nuclear-option-personal-story-of-treating-social-anxiety-with-5-meo-dmt/

The Sex Life of the Psychedelic Toad, by Paul Rydeen, Crash Collusion, 1993, https://erowid.org/archive/sonoran_desert_toad/rydeen.htm

The Sonoran Desert Toad, Psychedelic and Toxic, Jonathan Duhamel, Arizona Daily Independent, 2014, https://arizonadailyindependent.com/2014/05/18/the-sonoran-desert-toad-psychedelic-and-toxic/

The Toad and the Jaguar - Profound 5-MeO-DMT Experiences, By Ralph Metzner, The Nexian , August 2014, http://the-nexian.me/home/experience-reports/119-the-toad-and-the-jaguar-profound-5-meo-dmt-experiences

Toad medicine: a 5-Meo-Dmt trip into cosmic consciousness, By Xavier October 2017, https://xabtc.wordpress.com/2017/10/17/toad-medicine-a-5-meo-dmt-trip-into-cosmic-consciousness/

The Toad Nut/Mother, by Christian Raetsch, n.d, https://erowid.org/archive/sonoran_desert_toad/toadNut.htm

Toad-Smoking Gains On Toad-Licking Among Drug Users --- Toxic, Hallucinogenic Venom, Squeezed, Dried and Puffed, Has Others Turned Off, by Bill Richards, Wall Street Journal, 1994, https://erowid.org/archive/sonoran_desert_toad/wallstreet.htm

Toad Suckers: Not Just an Urban Myth, By Chris Kilham, Fox News, 2011, http://www.foxnews.com/health/2011/07/06/toad-suckers-not-just-urban-myth.html

Toad Venom: Weird Trip or Cancer Cure?, by Abby Haglage, The Daily Beast, 2017, http://www.thedailybeast.com/articles/2016/04/30/toad-venom-weird-trip-or-cancer-cure.html

Tripping over Psychoactive Toads, Harriet Dickinson, The Naked Scientists, 2009, https://www.thenakedscientists.com/articles/features/tripping-over-psychoactive-toads

'Watch a Freelance Journalist Writhe Through a Powerful DMT Trip for Research, Clinton Nguyen, Motherboard, 2015, https://motherboard.vice.com/en_us/article/watch-a-freelance-journalist-writhe-through-a-powerful-dmt-trip-for-research

What Is the Difference between 5-MeO DMT and DMT? Choosing a DMT Therapy, by Roger R, Psychedelic Times, 2016, http://psychedelictimes.com/dmt/what-is-the-difference-between-5-meo-dmt-and-dmt-choosing-a-dmt-therapy/

Why Venom Now? 5meo DMT as Entheogen, by Christopher G Ewing, The Practical Tripper, 2016, https://thepracticaltripper.wordpress.com/2016/11/25/why-venom-now-5meo-dmt-new-tradition/

5-MeO-DMT, By Mike Cernovich, Danger & Play, 2012, https://www.dangerandplay.com/2012/06/19/5-meo-dmt/

5-MeO-DMT, The Spirit Molecule, Pineal Gland, Consciousness, and Atheism, By Mike Cernovich, 2014  https://www.dangerandplay.com/2014/08/04/5-meo-dmt-spirit-molecule/

5-MeO-DMT, broken down and described, Disregard Everything I say, 2014, http://disregardeverythingisay.com/post/98109177114/5-meo-dmt-broken-down-and-described


41
Introductions/Newbies / Flux - Intro
« on: April 27, 2017, 03:49:33 AM »
Greetings

As one of the global moderators, and as an independent researcher, psychonaut, witness to the mystery and dabbler in various creative endeavours, welcome all. I hope this space provides an insightful, engaging and thoughtful dialogue with which to share our experiences with this incredible molecule and build community around our shared experiences of the ineffable.

Blessings,

Flux



42
Media/Resources / Videos
« on: April 27, 2017, 12:17:25 AM »
Vimeo

Awakenings: Dr Juan https://vimeo.com/83359280

James Oroc author of Tryptamine Palace€ discusses his 1st experience with 5-MeO-Dmt, https://vimeo.com/7711040

Martin Ball - 5 MEO-DMT, Energy, The Ego and Non-Duality, from Breaking Convention 2015 https://vimeo.com/138171763

Modern Uses of Ancient Medicines, Octavio Rettig, https://slideslive.com/38898649/modern-uses-of-ancient-medicines-toad-history

The Experiment at La Rosacita: Uncut File Footage, from Aya Awakenings https://vimeo.com/83370532

The Evolutionary Entrepreneur: From Ayahuasca to the 5-MEO-DMT Toad, Speaking the Unspeakable https://vimeo.com/159300747

The Toad of Dawn: 5-MeO-DMT and the Rise of Cosmic Consciousness https://vimeo.com/140204724

Toad to Nowhere https://vimeo.com/ondemand/toadtonowhere/175923297

5-MeO-DMT: What You Need to Know, The Drug Classroom 2017 https://vimeo.com/192228738


Youtube

Deep Toad, https://www.youtube.com/watch?v=iKp2WViqEGs

Dr. Octavio Rettig Hinojosa: 5MeODMT - The Sacred Toad, https://www.youtube.com/watch?v=NjYhDtkrN80

ERIE presents: Bufo Alvarius (Sonoran Desert Toad): 5-Meo-DMT and its role in humankind, https://www.youtube.com/watch?v=-S2WmtUCooo

Getting High with a Hallucinogenic Toad Prophet VICE  https://www.youtube.com/watch?v=cOFSX6nezEY

Licking the Toad and remembering that you're god: A 5-MeO DMT ceremony, https://www.michaelsanders.co/blog/rememberingyouregod

Ralph Metzner and 5 MeO DMT https://www.youtube.com/watch?v=4Q0oq90YJuc&t=2254s

"The GOD Molecule€, Psyched Substances  (5-MeO¦) https://www.youtube.com/watch?v=YxXdVVptwHo

The God Molecule 5 Meo Dmt Manchester Lecture With Dr.Gerry, Parts 1 to 6,
     https://www.youtube.com/watch?v=WQCuPEKuP6Y
     https://www.youtube.com/watch?v=ApM76OAmIGY
     https://www.youtube.com/watch?v=huL9X7g04K8
     https://www.youtube.com/watch?v=hAAymSaFHL4
     https://www.youtube.com/watch?v=4Cd0FmJSyIw
     https://www.youtube.com/watch?v=Uwgbt_L9AeE&t=4s

The Light of the Toad of Light (5-MeO-DMT) by Sebastian Job – filmed at Entheogenesis Australis 2016 https://www.youtube.com/watch?v=SvomF7t8bHw&feature=youtu.be

The Shamanic Toad Panel Discussion with Dean Jefferys, Rak Razam, Dan Schreiber and Jewelli Deva, https://www.youtube.com/watch?v=6bcuseyNwc4

Using 5-MeO-DMT To Become Enlightened - Interview With Martin Ball https://www.youtube.com/watch?v=bWSOl62memg

5-MeO-DMT Awareness Day: 'Cinco de Sapo'! with poem by The Teafaerie, Aware Project, https://www.youtube.com/watch?v=hr_0z2zEpWQ

5-MeO-DMT - The Magic Pill To Enlightenment & God https://www.youtube.com/watch?v=rH1bfZ1p6sg&t=2s



43
Media/Resources / Websites
« on: April 26, 2017, 02:33:06 AM »
Tryptamine Palace

Tryptamine Palace is a web-based information portal dedicated to the endogenous psychedelic entheogens, DMT (dimethyltryptamine), 5-MeO-DMT (5-methoxy-dimethyltryptamine), their animal and plant-analogues, (including ayahuasca, yopo, ebené, and Bufo alvarius toad venom), and their influence on the emerging global Visionary Culture. It is also intended as a entheogenic blog and 'e-companion' for the book "Tryptamine Palace: 5-MeO-DMT and the Sonoran Desert Toad' by James Oroc.

http://www.dmtsite.com/


DMT Nexus

The DMT-Nexus is a world-wide collaboration to provide information about DMT and other entheogens. This collaboration is open-ended, all-inclusive and open to revisions. This link directs to the DMT Nexus’ specific section on 5-MeO-DMT in all its forms.

Bufotenine and 5-MeO-DMT:

https://www.dmt-nexus.me/forum/default.aspx?g=topics&f=55


Erowid

Erowid is a member-supported organization providing access to reliable, non-judgmental information about psychoactive plants, chemicals, and related issues. Erowid works with academic, medical, and experiential experts to develop and publish new resources, as well as to improve and increase access to already existing resources. Erowid also strives to ensure that these resources are maintained and preserved as a historical record for the future. There is a section for 5-MeO-DMT with entries for ‘General Information’, ‘Related Vaults’, ‘History’, ‘Articles & Writings’, ‘Ask Erowid Answers’, ‘Experiences’ and ‘Books’.
 
https://erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml

Under ‘Animals’ section there is an entry for Psychoactive Toad Venom providing ‘General Information’, ‘Species & Varieties’, ‘Related Vaults’, ‘Health’, ‘Articles & Writing’, Research & Journal Articles’, ‘Media Coverage’ and ‘Experiences’ with links to external resources.

https://erowid.org/animals/toads/

There is also an archived vault specifically for the Sonoran Desert Toad with sections for ‘Required Reading’, ‘Scientific Research Papers’, ‘Toad Venom Particulars’, ‘Good Toad Stories’, ‘Newspaper Articles’ and ‘Other Toad Links’ and ‘Bibliography’.

https://erowid.org/archive/sonoran_desert_toad/index.htm

In the 'Experiences' Vault, there are some 333 Reports in total, with categories of 'general', 'first times', 'combinations', 'Retrospective/Summary', 'Preparation/Recipes', 'Difficult Experiences', 'Bad Trips', 'Health Problems', 'Train Wrecks & Trip Disasters', 'Addiction & Habituation', 'Glowing Experiences', 'Mystical Experiences', 'Health Benefits', 'Families' and 'What Was in That?'.

https://erowid.org/experiences/subs/exp_5MeODMT.shtml

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