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Biogenesis of 5-methoxy-N,N-dimethyltryptamine in human pineal gland

Started by Flux, May 01, 2017, 04:38:52 AM

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Guchhait RB, 1976, 'Biogenesis of 5-methoxy-N,N-dimethyltryptamine in human pineal gland', Journal of Neurochemistry, vol. 26, pp. 187-193, DOI: 10.1111/j.1471-4159.1976.tb04456.x,


The present report provides further insight about the controversial role of MTHF as a methyl donor for indoleamines. Attempts are also made to demonstrate the in vitro formation of 5 MeO DMT from indoleamine precursors by the human pineal extract using SAMe as the methyl donor. The identity of this biosynthetic product is supported by thin layer chromatographic procedures and by carrier crystallization technique.