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So You Want To Intramuscularly Administer 5-MeO-DMT HCl (or other salt)

Started by Handshake, September 30, 2017, 11:18:25 AM

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So You Want To Intramuscularly Administer 5-MeO-DMT HCl (or other salt)
by HumbleVoyager

Disclaimer: This information does not condone the activity it describes. Anything attempted is at one's own risk and knowledge that there are serious consequences if anything goes wrong in this process. Risks include, but are not limited to, infection, abscess, psychosis and injuries. This information is provided to help prevent problems that might arise if someone attempted this without appropriate information. Please PROCEED AT YOUR OWN RISK.

Materials Required:
-1 vial of bacteriostatic water containing .9% benzyl alcohol - 30ml is a good standard size.
-Sterile 10ml syringes with luer lock attachment.
-Any number of single-use, brand-new insulin syringes. I suggest using 1cc (1 ml) 27 to 31 gauge (31 gauge is nice and EasyComfort brand is ideal), 1/2 inch needles. 1 inch needles if you have a lot of fat in your thigh.
-Empty sterile vial with rubber membrane on top (10ml)
-.22μm (.22 micrometer) Micron filters.
-25 gauge, 1.5 inch hypodermic needles (Note that this is just needles, not with a syringe. These attach to the 10ml syringe.)
-Cotton balls or alcohol wipes
-Rubbing alcohol (isopropyl alcohol)
-Milligram scale (capable of weighing to .001g)
-Parchment paper

1. Acquire 5-MeO-DMT in a salted form (5-MeO-DMT HCl, 5-MeO-DMT Fumarate, 5-MeO-DMT Oxalate, etc.).

2. Make a calculation as to how you'd like to dose. I'd say that 10mg/ml is a good concentration. That way if you wanted to dose 5mg, you'd draw up .5cc's in your syringe. When you do an intramuscular injection, you really want as little fluid in there as possible.

3. Boil some water and pour the water into a bowl that has your bacteriostatic water vial in it. Allow the bacteriostatic water jar get hot. A hotter solvent dissolves the compound more quickly and efficiently.

4. While your bacteriostatic water is heating up, weigh out your 5-MeO-DMT. For a 10ml vial, you will need exactly 100mg of 5-MeO-DMT. It is best to weigh this on a square of parchment paper so that you can use the paper to move the powder.

5. Get one of your 10ml syringes, affix a needle onto the end, and remove the plunger. Into the barrel of the syringe, place the total amount of 5-MeO-DMT HCl (in this case you would be putting 100mg 5-MeO-DMT HCl). Then put the plunger back into the syringe, but don't push it down yet. Keep it at the top of the barrel.

6. Get your vial of warm bacteriostatic water. Insert the needle into the vial and turn the vial upside down so the needle is pointing up and push the plunger all the way up to the 5-MeO-DMT powder so that the vial gets filled with air. This will keep a vacuum from forming when removing the bacteriostatic water. Be careful to not go so far as to push any of the 5-MeO-DMT into the vial (this shouldn't be a problem, since you are moving directly to step 5).

5. Begin pulling the syringe back (it should actually be moving back on its own accord because you have created positive pressure in the bac water vial) and draw up 10ml or 10cc's of saline solution into the syringe. Make sure it fills up completely. Once you have 10ml of water in your syringe, remove the needle from the vial but draw up an extra 1cc of air into your vial.

6. Shake/rotate that syringe until the 5-MeO-DMT HCl has completely dissolved. It should just look like clear water when it is completely dissolved.

7. Hold the syringe with the needle facing up. Cap and remove the needle. Set it aside.

8. Screw on the micron filter and then screw on the needle to the output port of the filter.

9. Insert an extra needle into the side of the rubber top of the sterile vial without a syringe. This is to let air come out when you are adding the 5-MeO-DMT solution.

10. Insert the needle that is attached to the micron filter and syringe into your sterile, empty vial and depress the plunger. This will be a bit difficult to do and will require some strength. Be patient and let it go at its own pace.

11. Now your vial is a sterile, filtered solution ready for injections. Label the vial with the substance it contains AND THE CONCENTRATION. For example, this vial would read: 5-MeO-DMT HCl - 10mg/ml

12. Note: ALWAYS use a NEW NEEDLE. NEVER REUSE NEEDLES. You don't want to contaminate the sterile environment in that vial.

13. Now it's time to dose yourself. First, set up a clean, safe environment. Sterilize any surfaces you will be keeping your vial, syringes, and alcohol wipes. I have used a brand new cookie sheet for this purpose and have rubbed the whole thing down with rubbing alcohol to kill any bacteria. Set up any playlist you'd like for the experience at this point.

14. Wash your hands THOROUGHLY. You don't want any bacteria getting anywhere near the inside of your muscle.

15. This is best done with shorts of some kind or naked, because you will need access to your thigh. You can also inject into your deltoid muscle but that can be more painful and is hard to do on yourself. I will just talk about injecting into the thigh.

16. Take a good look at your thigh. You will want to divide it into four equal quadrants. Your injection should happen in the bottom-right quadrant for your right thigh or the bottom-left quadrant for your left thigh. If necessary, draw the quadrant lines.

17. Once you have determined where your injection site will be, sterilize the thigh by rubbing it in an outward spiral motion with your alcohol wipe, from the injection site outward. Take your time and make sure you don't miss a spot.

18. Let the rubbing alcohol dry.

19. Draw up your dose from your vial. Remember to double-check your dose as you do this to make sure you have the correct amount.

20. Hold the syringe in one hand like a dart. With your free hand, spread the skin on your thigh apart so it's tight. This will eliminate or at least significantly minimize any pain when you insert the needle.

21. Insert the needle at a 90 degree angle to your skin. You want to do this in one continuous motion, it doesn't have to be fast. Once it's in, I would suggest not letting the syringe move around so much. You can let go of the skin that is stretched now that the needle is in place and use it to steady the syringe.

22. Pull back on the plunger slightly to make sure you haven't hit any veins or arteries.

23. If there is NO blood registering in the barrel, you are good to go. Inject slowly and steadily. If you feel any pain or severe stinging, slow down your rate of injection. Breathe deeply as you do this. Sometimes people hold their breath.

24. Once you are done injecting, cap your needle and put it on your tray or somewhere that it won't be stepped on or otherwise messed with.

25. Lay down and dream with Love.

I hope this guide is helpful to anyone who wishes to take this sacrament in such a manner.

Love and Blessings.


You mention 5mg as a start off dosage, HV. Is that what you'd suggest that most people try for their first attempt with IM? I've seen much larger doses suggested in other parts of the forum that have worried me slightly.


Quote from: nottwo on October 02, 2017, 07:36:30 AM
You mention 5mg as a start off dosage, HV. Is that what you'd suggest that most people try for their first attempt with IM? I've seen much larger doses suggested in other parts of the forum that have worried me slightly.

Yes, I would say that 5mg IM would be a good low-moderate dose. 2.5mg might be a better place to start for someone naive to the substance. 10mg IM is enough for a full breakthrough for many.


another thing i am curious about is does the 5meo need to be synthetic or can organic 5meo be used


Thank you very much for sharing this excellent information, HumbleVoyager!  :) You do a great service to the community. I am highly intrigued about the IM ROA and do hope to try this myself sometime in the near future, it sounds like a great way of working with 5-MeO.

HostilisHead - high purity synthetic 5-MeO hcl is the best form of 5-MeO to use for IM injection. If you went with organic 5-MeO it would need to be of very high purity (and in salt form) and would likely require analytical testing to confirm this prior to use to be on the safe side.


You're quite welcome Banco. :)

@HostilisHead and Banco - when people say "organic" they are usually referring to toad venom. You should NEVER, UNDER ANY CIRCUMSTANCES inject ANY organic material unless it was highly purified to a crystalline consistency, run through several methods of filtration, AND verified via analytical testing. Impurities in organic substances could lead to serious problems if injected.


@HumbleVoyager is it possible to use freebase with this TEK or would anything need to change?
—surrender completes us—


Quote from: free-range on June 11, 2019, 09:29:12 AM
@HumbleVoyager is it possible to use freebase with this TEK or would anything need to change?

No, you cannot inject freebase. It must be in salt form. Note that step one is to acquire 5-MeO-DMT in salted form.


A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting

Presentation discussing the results of the study:  Vaporization or intramuscular injection of synthetic 5-MeO-DMT

A small survey study, in which respondents who used the IM ROA were less likely to experience reactivations.  While I don't see this in the paper, in the video one of the authors theorizes that this may be due to the slower onset of the effect, which would be less shocking to the nervous system than the quick onset from vaporization.  It definitely makes me more curious about non-vaporization ROAs in general.

I also wonder if doing a handshake dose before a flood dose would decrease the chance/frequency of reactivations, as your nervous system would have a chance to feel into the effects of the molecule a bit more gently?  Anecdotally, of the dozen or so people I know that met the molecule through a handshake dose initially, none experienced large, ongoing reactivations.   


That's really great to know! Less shock to the system = less reactivations


it's shocking to me this thread isn't more robust.

IM seems like the ROA that makes much sense with 5.
this is of course coming from someone very new to the medicine but the way it's so gradual is like sinking into the ocean rather than suddenly being
submerged within the depths.

would love to hear more about this topic.  dosing, what consittutes a breakthrough.  how often this "ought" to be used.



hmmm, maybe I'm using the word incorrectly.

more lively?

it seems like a ROA that isn't super well known (among local peeps I'm the only person to have done it, and I live in a large city)

and one that is very stable and beneficial so just figured peeps would be as excited as I am and it would be bustling :)


Ah, thanks for clarifying!

I imagine this ROA is not as common or popular because many people are (rightfully so) hesitant to inject drugs, and especially when said drug hasn't been tested and is very potent.

It's significantly more risky than pretty much every other ROA, besides perhaps the danger of burning one's self or setting something on fire if vaporizing.


yeah I totally understand the ideology about injecting.

the reality tho is it's the most sterile, reliable means. (I know I'm preaching to the choir here)

its' used in hospitals for good reason!   

and aside from possibly hitting a vein (which is very very low probability, I've done more than 1000 im injections and never had one)
I think the risk is pretty much nil.   unless you include using impure medication or dirty tools.

and people seem not to be able to distinguish between IV and IM.(not saying you are, as know you to be educated in this)    IV has a bunch of risk factors, embolism, absessing from a miss, blowing veins, blood infection etc. 
but im is pretty damn safe and convenient.

ok I swear I'm not paid by the intramuscular foundation ;)
I just really dig it.

I started macrodosing LSD via IM as well (liquid ovbi) and it's again just reliable af.   no variable in digestion based on what I ate, or how my stomach acid is working, etc.