Started by Flux, January 24, 2018, 02:45:17 AM
Quote from: Flux on January 24, 2018, 02:45:17 AMWell this got my attention... (although I cannot imagine anyone having enough 5-MeO-DMT to explore this on anything other than a micro scale;"Alexander Shulgin has explained that it could be possible to cultivate 4-HO-5-MeO-DMT in psilocybin mushrooms by adding 5-MeO-DMT to the growing substrate of the fungus". https://en.wikipedia.org/wiki/4-Hydroxy-5-methoxydimethyltryptamine
Quote from: HumbleVoyager on January 24, 2018, 06:25:12 AMFascinating! I remember this idea going around many times with various substances. For further reading, this paper seems of interest to understand the method more deeply (see paper attached).It seems also fair to say that one would have no idea what would happen in vivo with that added hydroxy group. There has also been speculation that the fungi would only modify some tryptamine compounds (such as DET or DPT) yet not others, though I think further reading/investigation would be required. A curious concept, and a potential for synthesis, as I imagine one could theoretically produce 4-HO-5-MeO-DMT and then remove the 4-HO and end up with a pure extraction of 5-MeO-DMT. All speculation but intriguing nonetheless.
Quote from: HumbleVoyager on January 28, 2018, 08:56:07 AMHey there RoundAbout, I fixed the PDF for you. Sorry about that! You should be able to download and read now. Let me know if you still aren't able to.In the paper, they talk about how when they did the experiment, the fungi stopped producing psilocin or psilocybin and instead were producing the phosphorylated compound 4-HO-DET (if I remember correctly). It also seems the quantity they got out was greater than what was put in, so perhaps once the fungi start producing the 4-HO compounds, they forget about the psilocin and psilocybin. It is a well-written paper, with a well-documented methodology.
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