Author Topic: Human intranasal, sublingual and oral pharmacology of 5-methoxy-N,N-dmt  (Read 1049 times)

Offline Flux

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Ott J, 2011, 'Pharmepena-Psychonautics: Human Intranasal, Sublingual and Oral Pharmacology of 5-Methoxy-N, N-Dimethyl-Tryptamine', Journal
Journal of Psychoactive Drugs
, vol. 33, 2001, no. 4,


Summarized are psychonautic bioassays (human self-experiments) of Pharmepena - crystalline 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT; O-Me-bufotenine), at times combined with crystalline b-Carboline (harmaline or harmine). These substances were administered via intranasal, sublingual and oral routes, by way of pharmacological modeling of diverse South American shamanic inebriants (principally the snuffs epena/nyakwana, prepared from barks of diverse species of Virola.) Intranasal, sublingual and oral psychoactivity of 5-MeO-DMT, and the 1967 Holmstedt-Lindgren hypothesis of the parica-effect - intranasal potentiation of tryptamines by concomitant administration of monoamine-oxidase-inhibiting (MAOI) b-Carboline from stems of Banisteriopsis caapi admixed with the snuffs - have been confirmed by some 17 psychonautic bioassays. Salient phytochemical and psychonautic literature is reviewed.
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