Near the beginning of my 5-MeO-DMT use, I had an intense 1-week period of reactivations that was very difficult to deal with. Like your brother, it was more or less continuous where I'd have symptoms during both day and night. Thankfully it eventually tapered off around day 6, which I expect your brother's experience will as well at some point. It may not seem like it to him in the moment, but he should know that he'll likely be fine if he can just hold on.
As far as mitigating the worst of it, the advice from The Conclave is the best I've found. That includes exercise, acupuncture, "grounding" foods, etc. But the one that worked best for me when I was really having extreme effects was sedatives/anti-anxiety medication that focuses on GABA. And if he wants to go the more natural route (which is what I did), he could use the supplement GABA itself or another supplement called Kava. Either of those should temporarily calm down the energetic madness of reactivations.
Conclave integration guidelines: https://assets-global.website-files.com/5dab753665b2d985ff08d69b/5dab753665b2d9d9c808d6cd_Integration-Guidelines-CONCLAVE-28.05.18.pdf
As far as mitigating the worst of it, the advice from The Conclave is the best I've found. That includes exercise, acupuncture, "grounding" foods, etc. But the one that worked best for me when I was really having extreme effects was sedatives/anti-anxiety medication that focuses on GABA. And if he wants to go the more natural route (which is what I did), he could use the supplement GABA itself or another supplement called Kava. Either of those should temporarily calm down the energetic madness of reactivations.
Conclave integration guidelines: https://assets-global.website-files.com/5dab753665b2d985ff08d69b/5dab753665b2d9d9c808d6cd_Integration-Guidelines-CONCLAVE-28.05.18.pdf