Author Topic: 5 with maoi rectal  (Read 121 times)

Offline celestino

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5 with maoi rectal
« on: June 08, 2019, 12:25:19 PM »
hi everyone,

yesterday evening it was my 4th immersion in 5HCL with syrian rue extract/100mg) 30 mnts before applying 6 mg rectally. onset began 15 mnts after doing

the 5, this time I felt the hand of the molecule;peacefulness, gratefulness and little thinking activity, listening to music lying down (savasana) it lasted for 1/2

hours,the other 3 times I did 3mg5 / 50 mg extract, then a week later 4mg 5 / 100mg extract, then 5 mg 5 / 100 mg extract,all of these a buzz in the ears , I

think it is the increase of energy level.

next time in a week I will do 7mg 5 / 100mg extract. some people are known to go as high as 9mg 5. I was told that I would begin to feel the effects  in the

range 6/7 mg 5. It also seems the effects are not linear. All of this guided by my good and experienced fríend Malcom Z.

cheers, light and love .

   _/|\_ O0 <3

Offline HumbleVoyager

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Re: 5 with maoi rectal
« Reply #1 on: June 11, 2019, 09:54:36 AM »
Be very careful. People have died using 5-MeO-DMT in combination with MAOIs.

Offline celestino

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Re: 5 with maoi rectal
« Reply #2 on: June 12, 2019, 01:19:03 PM »

hi humble Voyager,

would you please tell me the facts and the names of the people who have died because of 5 + maoi?

in yopo it is used maoi and no problem, the danger is if 5 is taken orally with maoi , NOT RECTALLY.

Will you please tell me where from did you get this information? thanks

all the best. celestino


Offline RoundAbout

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Re: 5 with maoi rectal
« Reply #3 on: June 13, 2019, 10:43:51 AM »
the danger is if 5 is taken orally with maoi , NOT RECTALLY.

Why would oral + MAOI be more dangerous than rectal + MAOI? If it was similarly dangerous, I would expect no reports of fatalities or permanent effects due to the lack of popularity, as less people administer rectally than orally and even fewer combine rectal with an MAOI. It wouldn't make sense if someone said administering intravenously with an MAOI was very safe on the basis of lack of evidence either, would it?

Also, isn't yopo dominantly bufotenine?
« Last Edit: June 13, 2019, 10:48:09 AM by RoundAbout »

Offline celestino

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Re: 5 with maoi rectal
« Reply #4 on: June 14, 2019, 01:27:12 AM »
hi,

it is a bit like cooking in 2 different pots, the substances don´t mix up, they work from different places, so no danger.

yesterday evening my 5th immersion  , 7mgs 5 and 30 mnts before 100 mgs harmala extract.

effects come up after 15 mnts, back to base line 2 hours. this time a quite and peaceful mind, very few thoughts rising, conscious of my surroundings,

consciousness felt mainly in the forehead. i would call this experience, "the god/godess of little things".

all the best. _/|\_

Offline physics envy

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Re: 5 with maoi rectal
« Reply #5 on: June 14, 2019, 05:43:59 PM »
Why would oral + MAOI be more dangerous than rectal + MAOI?


Generally oral ingestion of a substance goes through the liver and is broken down/converted, while rectal administration may or may not go through the liver.


I don't know all the details, but from reading up on using cannabis oil suppositories, it depends on how deep you administer.


If you stay in the first 1.5inches or so of the rectum, the substance does not get routed through the liver, but if you insert deeper, the substance may indeed be routed through the liver.


I don't know if this affects 5+maoi combinations at all, but I think that's the main difference between oral and rectal administration.

Offline celestino

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Re: 5 with maoi rectal
« Reply #6 on: June 15, 2019, 01:40:15 AM »


thank you  physics envy. _/|\_

Offline RoundAbout

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Re: 5 with maoi rectal
« Reply #7 on: June 20, 2019, 02:41:26 PM »
hi,

it is a bit like cooking in 2 different pots, the substances don´t mix up, they work from different places, so no danger.

I don't see the basis for your analogy. Sounds superstitious.
Why would oral + MAOI be more dangerous than rectal + MAOI?


Generally oral ingestion of a substance goes through the liver and is broken down/converted, while rectal administration may or may not go through the liver.


I don't know all the details, but from reading up on using cannabis oil suppositories, it depends on how deep you administer.


If you stay in the first 1.5inches or so of the rectum, the substance does not get routed through the liver, but if you insert deeper, the substance may indeed be routed through the liver.


I don't know if this affects 5+maoi combinations at all, but I think that's the main difference between oral and rectal administration.

OK, but that doesn't say too much about safety (as you acknowledge).

The peak concentrations of metabolites is probably lower if first pass metabolism is avoided (and obviously lower doses are required), but what bearing does that have for safety? The metabolites of 5-MeO-DMT are a complicating factor, especially given the impact of enzyme polymorphism (e.g. 5-OH-DMT as a metabolite), but I haven't seen anything to suggest that rectal + MAOI is somehow fundamentally more safe than oral or vaporized + MAOI. Some people seem to handle it fine, other don't (to put it lightly).
« Last Edit: June 20, 2019, 02:44:47 PM by RoundAbout »